abstract：:To investigate the effect of stimulus presentation rate on the activity of primary somatosensory cortex, we performed echo-planar functional magnetic resonance imaging using a 1.5-tesla magnetic resonance system. Eight right-handed normal volunteers underwent functional magnetic resonance imaging during somatosensory ...

journal_title：Brain research bulletin

authors： Takanashi M,Abe K,Yanagihara T,Oshiro Y,Watanabe Y,Tanaka H,Hirabuki N,Nakamura H,Fujita N

更新日期：2001-01-15 00:00:00

abstract：:Induction of expression of immediate-early gene c-Fos in the striatum is a common effect of many drugs of abuse, including morphine. Previous studies have shown that the morphine-mediated c-Fos response is attenuated by antagonists of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor. Other evidence sugges...

journal_title：Brain research bulletin

authors： Harlan RE,Webber DS,Garcia MM

更新日期：2001-01-15 00:00:00

abstract：:Progesterone receptor (PR) isoforms expression was determined in several regions of the prepuberal and adult male rat brain by using reverse transcription coupled to polymerase chain reaction. Rats under a 14:10-h light-dark cycle, with lights on at 0600 h were used. We found that in the hypothalamus of prepuberal ani...

journal_title：Brain research bulletin

authors： Guerra-Araiza C,Reyna-Neyra A,Salazar AM,Cerbón MA,Morimoto S,Camacho-Arroyo I

更新日期：2001-01-01 00:00:00

abstract：:In experimental studies on peripheral nerve repair, the possibility to objectively compare original and post-operative innervation is of decisive importance for the selection of the proper nerve-reconstruction strategy. Herewith we report serious drawbacks encountered with the standard method of pre- and post-operativ...

journal_title：Brain research bulletin

authors： Popratiloff AS,Neiss WF,Skouras E,Streppel M,Guntinas-Lichius O,Angelov DN

更新日期：2001-01-01 00:00:00

abstract：:The assumption was made that investigatory behaviors (i.e., ano-genital and general body sniffing) of a female conspecific by a mature male rat, has positive hedonic characteristics. Because reduced interest in pleasurable events (i.e., anhedonia) is diagnostically related to depressive behavior, the hypothesis was ad...

journal_title：Brain research bulletin

authors： Paré WP

更新日期：2000-12-01 00:00:00

abstract：:The nucleus locus coeruleus (LC) has been implicated in the modulation of the spinal sensorimotor function. The aim of the present study was to examine the effect of electrical stimulation of the LC on sensorimotor function in the trigeminal system. The following two cases of sensorimotor behaviors mediated by the tri...

journal_title：Brain research bulletin

authors： Matsutani K,Tsuruoka M,Shinya A,Furuya R,Kawawa T

更新日期：2000-12-01 00:00:00

abstract：:Investigation of the differentiation of electrical properties of motoneurons has been stimulated by the importance of these neurons for embryonic behavior and facilitated by their experimental accessibility. In this review, we examine the development of different patterns of excitability and their functions, and discu...

journal_title：Brain research bulletin

authors： Spitzer NC,Vincent A,Lautermilch NJ

更新日期：2000-11-15 00:00:00

abstract：:Motor neurons are endowed with intrinsic and conditional membrane properties that may shape the final motor output. In the first half of this paper we present data on the contribution of I(h), a hyperpolarization-activated inward cation current, to phase-transition in motor neurons during rhythmic firing. Motor neuron...

journal_title：Brain research bulletin

authors： Kiehn O,Kjaerulff O,Tresch MC,Harris-Warrick RM

更新日期：2000-11-15 00:00:00

abstract：:Creatine kinase reaction rates were measured by the magnetisation transfer technique in brains of healthy adult and aged rats and in rats with chronic cerebral ischemia and chronic ethanol intoxication. These measurements indicated that the rate constant of the creatine kinase reaction is significantly reduced in the ...

journal_title：Brain research bulletin

authors： Kasparová S,Dobrota D,Mlynárik V,Pham TN,Liptaj T,Horecký J,Braunová Z,Gvozdjáková A

更新日期：2000-11-01 00:00:00

abstract：:It has been demonstrated that the posteromedial cortical amygdaloid nucleus (PMCo), is sexually dimorphic. It is shown (Experiment 1) that male orchidectomy on the day of birth (D1) decreases the volume and number of neurons of the PMCo, while a single injection of propionate testosterone to the female on D1 masculini...

journal_title：Brain research bulletin

authors： Vinader-Caerols C,Collado P,Segovia S,Guillamón A

更新日期：2000-10-01 00:00:00

abstract：:Using microdialysis, the effects of endogenous dopamine on basal extracellular concentrations of gamma-aminobutyric acid (GABA) and on the increases of GABA produced by glutamate were investigated in the medial prefrontal cortex of the awake rat. The dopamine uptake inhibitor nomifensine (1, 100 and 1000 microM), used...

journal_title：Brain research bulletin

authors： Del Arco A,Mora F

更新日期：2000-10-01 00:00:00

abstract：:Prenatal cocaine exposure increases mu-opioid receptor binding in dopaminergic terminal areas and enhances behavioral responsiveness to mu-opioid agonists. We investigated the influence of early postnatal cocaine treatment on in vitro mu- and delta-opioid receptor activation in male and female weanling rats. Pups rece...

journal_title：Brain research bulletin

authors： Meyer JS,Shani I,Rice D

更新日期：2000-09-15 00:00:00

abstract：:In recent years, increasing number of data indicate that cerebral structures exert a direct, pituitary-independent, neural regulatory action on the endocrine glands. In addition, both experimental and clinical observations indicate functional asymmetry of the control system. Therefore, the objective of the present stu...

journal_title：Brain research bulletin

authors： Banczerowski P,Csaba Z,Csernus V,Gerendai I

更新日期：2000-09-15 00:00:00

abstract：:Measurements were made in 29 adult baboons that were housed in social groups, allowing the occurrence of the full range of species-specific behavioral interactions. The cardiovascular variables measured included blood pressure, heart rate, renal blood flow, lower limb blood flow, and occasionally mesenteric blood flow...

journal_title：Brain research bulletin

authors： Smith OA,Astley CA,Spelman FA,Golanov EV,Bowden DM,Chesney MA,Chalyan V

更新日期：2000-09-01 00:00:00

abstract：:The involvement of alpha-amino-3-hydroxy-5-methylizoxazole-4-propionic acid (AMPA) receptors in induction of long-term potentiation (LTP) was examined in rat hippocampal slice preparation. Using conventional extracellular recording, excitatory postsynaptic potentials (EPSPs) and population action potentials (PSs), evo...

journal_title：Brain research bulletin

authors： Kapus G,Székely JI,Durand J,Ruiz A,Tarnawa I

更新日期：2000-08-01 00:00:00

abstract：:The inhibition of excitatory mechanisms by components of low molecular weight, isolated from spiders and solitary wasps, such as, the acyl-polyamines, has demonstrated, on the one hand, neuroprotection potential, and on the other hand, it is well known that some arthropod venom components have convulsant activity. Whi...

journal_title：Brain research bulletin

authors： Ribeiro AM,dos Santos WF,Garcia-Cairasco N

更新日期：2000-08-01 00:00:00

abstract：:The neuronal networks of the frontal lobe that represent motor or executive memories are probably the same networks that cooperate with other cerebral structures in the temporal organization of behavior. The prefrontal cortex, at the top of the perception-action cycle, plays a critical role in the mediation of conting...

journal_title：Brain research bulletin

authors： Fuster JM

更新日期：2000-07-15 00:00:00

abstract：:To determine whether repeated exposure of cocaine affects the dopaminergic innervation of the nucleus accumbens, we employed a typical cocaine-dosing regimen in adult male Sprague-Dawley rats followed by an immunocytochemical analysis of tyrosine hydroxylase (TH). Treatment consisted of bi-daily injections of saline o...

journal_title：Brain research bulletin

authors： Todtenkopf MS,De Leon KR,Stellar JR

更新日期：2000-07-15 00:00:00

abstract：:Some C57Bl/6 mice become obese, whereas others remain lean when raised on a high-fat diet. The mechanisms underlying this interindividual susceptibility to diet-induced obesity remain unknown. Because hypothalamus plays a major role in the regulation of body weight, this study was conducted to identify the differences...

journal_title：Brain research bulletin

authors： Xin X,Storlien LH,Huang XF

更新日期：2000-07-01 00:00:00

abstract：:We have found that thiamine-deficient (TD) rats show significant impairment of avoidance learning on the 25th day after the start of TD diet, as measured by passive-avoidance task. Administration of physostigmine (0.1 mg/kg, i.p.) from the 14th day after the start of TD diet improved the impairment of avoidance learni...

journal_title：Brain research bulletin

authors： Nakagawasai O,Tadano T,Hozumi S,Tan-No K,Niijima F,Kisara K

更新日期：2000-06-01 00:00:00

abstract：:The presence of glial cell line-derived neurotrophic factor (GDNF) is described within specific regions of the adult rat pituitary gland. Immune staining methods revealed a small number of GDNF-immunopositive cells in the anterior lobe, and in areas of the neural lobe, while no immunoreactive endocrine cells were obse...

journal_title：Brain research bulletin

authors： Saland LC,Cunningham LA,Su C,Morales M,Gaddy J

更新日期：2000-05-15 00:00:00

abstract：:Nagase genetically analbuminemic rats (NAR) were run to fatigue. Administration of branched chain amino acids (BCAA) before exhaustive exercise, resulted in a post-fatigue decreased tryptophan uptake (-22%, p < 0.05) and 5-hydroxytryptophan (5-HTP) uptake (-29%, p < 0.01) into the synaptosomes isolated from the striat...

journal_title：Brain research bulletin

authors： Yamamoto T,Newsholme EA

更新日期：2000-05-01 00:00:00

abstract：:The serotonin(2A) (5HT(2A)) receptors have been shown to play an important role in several psychiatric disorders, including depression, schizophrenia, and alcoholism. This immunohistochemical study examined the cellular localization of 5HT(2A) receptors in various rat brain structures (olfactory, striatum, cortex, hip...

journal_title：Brain research bulletin

authors： Xu T,Pandey SC

更新日期：2000-04-01 00:00:00

abstract：:The interaction between nitric oxide (NO) and the release of [(3)H]noradrenaline ([(3)H]NA) in conditions of non-activated and activated nicotinic receptors in guinea-pig gastric fundus preincubated with [(3)H]NA was studied. Nicotinic receptor agonist, 1,1-dimethyl-4-phenyl-piperazinium iodide (DMPP) (100 microM) sig...

journal_title：Brain research bulletin

authors： Sotirov E,Papasova M

更新日期：2000-03-15 00:00:00

abstract：:It is now generally accepted that adenosine has a neuroprotective role in the central nervous system. Agonists of adenosine such as 2-chloroadenosine (2-ClA) have been shown to be neuroprotective, while antagonists such as 8-phenyltheophylline (8-PT) increase neurotoxicity. However, paradoxical results have been repor...

journal_title：Brain research bulletin

authors： Brooke SM,Sapolsky RM

更新日期：2000-03-01 00:00:00

abstract：:The glucostatic theory supports the role of central and peripheral substrate "sensors" in monitoring cellular glucose metabolism. Induction of hyperphagia and hyperglycemia by intracerebroventricular (i.c.v.) delivery of drugs inhibiting glucose uptake or oxidation suggests that glucose "sensors" are accessible from t...

journal_title：Brain research bulletin

authors： Briski KP

更新日期：2000-02-01 00:00:00

abstract：:In this study, we examine the utility of computational modeling in understanding nervous system function. We start by examining the reasons for, and major approaches to, computational modeling. We then chose a modeling approach and applied different variations to understanding nucleus tractus solitarius (NTS) neuronal...

journal_title：Brain research bulletin

authors： Rogers RF,Rybak IA,Schwaber JS

更新日期：2000-01-15 00:00:00

abstract：:In rats, on the 25th day after the start of a thiamine-deficient (TD) diet, impairment of avoidance learning was significantly induced in proportion to the decrease somatostatin (SST) fluorescence intensity in the cortex, amygdala, thalamus, hypothalamus, and hippocampus, including the CA1, CA2, and dentate gyrus (DG)...

journal_title：Brain research bulletin

authors： Nakagawasai O,Tadano T,Niijima F,Tan-No K,Kisara K

更新日期：2000-01-01 00:00:00

abstract：:To investigate nitric oxide production in the brain of the EL mouse, an inbred mutant strain of the ddY mouse that is susceptible to convulsive seizures, we measured whole brain nitric oxide metabolites, and counted the number of nitric oxide-producing cells in the parietal cortex and striatum. Nitric oxide metabolite...

journal_title：Brain research bulletin

authors： Uchida M,Nagatomo I,Akasaki Y,Tominaga M,Hashiguchi W,Kuchiiwa S,Nakagawa S,Takigawa M

更新日期：1999-11-01 00:00:00

abstract：:The effect of regucalcin, a Ca(2+)-binding protein, on Ca(2+)-dependent protein kinase activity in the brain cytosol of rats with different ages (5 and 50 weeks old) was investigated. The addition of calmodulin (10 microg/ml) or dioctanoylglycerol (5 microg/ml) in the enzyme reaction mixture caused a significant incre...

journal_title：Brain research bulletin

authors： Hamano T,Hanahisa Y,Yamaguchi M

更新日期：1999-10-01 00:00:00

abstract：:Entrainment of the dominant circadian pacemaker localised to the hypothalamic suprachiasmatic nuclei (SCN) is mediated partially via the indirect retino-geniculo-hypothalamic projection to the SCN, which is presumed to utilise enkephalin and other neurotransmitters, to modulate circadian rhythmicity. In the present st...

journal_title：Brain research bulletin

authors： Cutler DJ,Mundey MK,Mason R

更新日期：1999-09-15 00:00:00

abstract：:There are cholinergic inputs responsible for pressor responses in the rostral ventrolateral medulla (RVLM) and stimulation of midbrain central gray (CG) increases arterial pressure via activation of neurons in the RVLM. In this study, we examined whether the CG was involved in mediation of the cholinergic inputs to th...

journal_title：Brain research bulletin

authors： Kubo T,Hagiwara Y,Sekiya D,Fukumori R

更新日期：1999-09-01 00:00:00

abstract：:Creutzfeldt-Jakob disease (CJD) and other transmissible spongiform encephalopathies (TSEs) are characterised by the accumulation of a pathological conformer of PrP, named PrPsc. Molecular weight and glycosylation of the protease-resistant core of PrPsc (PrP27-30) are heterogeneous in different forms of TSEs. We analys...

journal_title：Brain research bulletin

authors： Cardone F,Liu QG,Petraroli R,Ladogana A,D'Alessandro M,Arpino C,Di Bari M,Macchi G,Pocchiari M

更新日期：1999-08-01 00:00:00

abstract：:The antidepressant desipramine has been shown to decrease synaptic membrane concentrations of the norepinephrine re-uptake transporter (NET) in vivo and in vitro, on both an acute and a chronic basis. The possible contribution of decreased NET synthesis to the chronic downregulation of the NETs has not been definitive...

journal_title：Brain research bulletin

authors： Zavosh A,Schaefer J,Ferrel A,Figlewicz DP

更新日期：1999-07-01 00:00:00

abstract：:Progressive disruption of both the neuroendocrine and immune systems has been correlated with age-associated pathogenesis in patients with Alzheimer's disease and in mice lacking apolipoprotein E (ApoE). In this study, we examined neuroautoimmune and neuroendocrine activities in relation to aging and stress in ApoE-de...

journal_title：Brain research bulletin

authors： Zhou Y,Cheshire A,Howell LA,Ryan DH,Harris RB

更新日期：1999-06-01 00:00:00

abstract：:Hippocampal theta activity is a large amplitude, sinusoidal wave that occurs during attentive immobility and exploratory behaviour in the rat, and it is thought to be involved in memory formation. Recent reports suggest that corticotropin-releasing hormone (CRH) has pro-mnemonic effects in rodents. Because memory-enha...

journal_title：Brain research bulletin

authors： Kortekaas R,Costall B,Smythe JW

更新日期：1999-04-01 00:00:00

abstract：:Saturation and competition binding studies showed that the turtle brain contains sigma sites labeled by both [3H]di-o-tolylguanidine (DTG) and [3H](+)-pentazocine. There was a significant correlation between the IC50 values of sigma ligands for [3H]DTG sites in the turtle vs. rat brain, suggesting that the sites are c...

journal_title：Brain research bulletin

authors： Matsumoto RR,Bowen WD,de Costa BR,Houk JC

更新日期：1999-03-15 00:00:00

abstract：:The anticonvulsant drug Diazepam (DIA-2 mg/kg b. wt), the nitric oxide (NO) donor L-Arginine (L-Arg-2000 mg/kg b. wt) and the putative nitric oxide synthase (NOS) inhibitor N(G)-Nitro-L-Arginine methyl ester (L-NAME-50 mg/kg b. wt) were used to determine the role of endogenous NO on convulsions induced by picrotoxin (...

journal_title：Brain research bulletin

authors： Jayakumar AR,Sujatha R,Paul V,Puviarasan K,Jayakumar R

更新日期：1999-03-01 00:00:00

abstract：:The susceptibility of the developing brain to hypoxia should depend on the lipid composition of the brain cell membrane; the rate of lipid peroxidation; the presence of antioxidant defenses; and the development and modulation of the excitatory neurotransmitter receptors such as the N-methyl-D-aspartate (NMDA) receptor...

journal_title：Brain research bulletin

authors： Mishra OP,Delivoria-Papadopoulos M

更新日期：1999-02-01 00:00:00

abstract：:The effects of intrathecally (i.t.) administered naloxone or glibenclamide, a blocker of adenosine triphosphate-sensitive potassium (KATP) channels, on the antinociception produced by i.t. apomorphine were observed by an integrated electromyogram measurement of hindlimb flexor reflex in lightly pentobarbital-anestheti...

journal_title：Brain research bulletin

authors： Hu WM,Kang YM,Qiao JT

更新日期：1999-02-01 00:00:00